Surgery Trials

1. A Phase III Randomized Trial of Lobectomy Versus Sublobar Resection for Small (≤ 2 CM) Peripheral Non-Small Cell Lung Cancer

ClinicalTrials.gov Identifier: NCT00499330

Wedge resection or segmentectomy may be less invasive types of surgery than lobectomy for non-small cell lung cancer and may have fewer side effects and improve recovery. It is not yet known whether wedge resection or segmentectomy are more effective than lobectomy in treating stage IA non-small cell lung cancer.
Ontario
St. Joseph's Hospital - Charlton Campus, Hamilton
London Regional Cancer Centre, London
Princess Margaret Hospital, Toronto
Ottawa Regional Cancer Centre, Ottawa

Quebec
Hopital Notre-Dame du CHUM, Montreal
CHUS-Hopital Fleurimont, Sherbrooke
L'Hopital Laval, Laval

British Columbia
Surrey Memorial Hospital, Surrey

2. Robotic Lobectomy vs. Thoracoscopic Lobectomy for Early Stage Lung Cancer

ClinicalTrials.gov Identifier: NCT02617186

Robotic lobectomy has been shown, on the basis of non-randomized studies, to have superior outcomes to thoracotomy and Thoracoscopic lobectomy. Despite the potential benefits of robotic technology, there are two major barriers against its widespread adoption in thoracic surgery. The first barrier is the lack of high-quality prospective data. To our knowledge, there are no prospective trials comparing Thoracoscopic Lobectomy to Robotic Lobectomy for early stage lung cancer. The second major barrier to the widespread adoption of robotic technology in thoracic surgery is the perceived higher cost of Robotic lobectomy. To address these barriers, the investigators will undertake the first randomized controlled trial comparing Thoracoscopic Lobectomy to Robotic Lobectomy for early stage lung cancer. Prospective randomization will eliminate the biases of retrospective data and will serve to determine whether there exist any advantages to HRQOL or patient outcomes in favour of Robotic Lobectomy over Thoracoscopic Lobectomy. Furthermore, through a prospective cost-utility analysis, this trial will provide the highest quality data to evaluate the true economic impact of robotic technology in thoracic surgery.
Ontario
St Joseph’s Healthcare, Hamilton
Toronto General Hospital, Toronto

3. Randomized Study of Preoperative Dexamethasone for Quality of Recovery in VATS Lung Resection Patients (APV)

ClinicalTrials.gov Identifier: NCT02275702

The proposed study is a randomized, double-blind, placebo-controlled evaluation if a small dose of IV dexamethasone during induction anesthesia in association to pre and postoperative intercostal nerve block, improves quality of recovery of thoracoscopic lung resection patients.
Quebec
Institut Universitaire de Cardiologie et de Pneumologie de Qu├ębec, Quebec City

4. Ultrasonic Energy for Pulmonary Artery Branch Sealing During VATS Lobectomy (VATS PA-ACE)

ClinicalTrials.gov Identifier: NCT02719717

This research program consists of a prospective, multi-institutional Phase 2 trial and an economic cost-effectiveness analysis for the use of ACE+7 in VATS lobectomy/segmentectomy compared to traditional techniques. It will be left up to the study credentialed surgeon investigator to decide the suitability of PA branches for sealing. This will be decided intra-operatively based on anatomy, vascular dissection and length as well as patient specific factors.
Quebec
Centre Hospitalier de l'Universite de Montreal, Montreal

5. Cervical Video Assisted Thoracoscopic Surgery (C-VATS) (CT0030)

ClinicalTrials.gov Identifier: NCT01440244

Although thoracic NOTES may not be ready for human trials, a new minimally invasive technique to access the pleural cavity and perform pleural, pulmonary and mediastinal procedures would be possible. Cervical Video Assisted Thoracoscopic Surgery (C-VATS) is a technique that borrows from traditional VATS procedures, from cervical mediastinoscopy, and from flexible endoscopy. All of these procedures are very familiar to the thoracic surgeon. The current feasibility and safety study examines C-VATS as a method of evaluating, biopsying and performing pleurodesis in patients with pleural disease and or effusion.
Quebec
Centre Hospitalier de l'Universite de Montreal, Montreal