1.High-Dose or Standard-Dose Radiation Therapy and Chemotherapy With or Without Cetuximab in Treating Patients With Newly Diagnosed Stage III Non-Small Cell Lung Cancer That Cannot Be Removed by Surgery
ClinicalTrials.gov Identifier: NCT00533949
PURPOSE: This randomized phase III trial is studying high-dose or standard-dose radiation therapy given together with chemotherapy with or without cetuximab to see how well they work in treating patients with newly diagnosed stage III non-small cell lung cancer that cannot be removed by surgery and if Overall Survival is improved.
QC
Hopital Notre Dame, Montreal
SK
Saskatoon Cancer Center, Saskatoon
Allan Blair Cancer Center, Regina
ON
Princess Margaret Hospital, Toronto
MB
Cancer Care Manitoba, Winnipeg
AB
Tom Baker Cancer center, Calgary
2.Randomized Phase II Study Comparing Prophylactic Cranial Irradiation Alone to Prophylactic Cranial Irradiation and Consolidative Extra-Cranial Irradiation for Extensive Disease Small Cell Lung Cancer
ClinicalTrials.gov Identifier: NCT01055197
This randomized phase II trial is comparing how well radiation therapy to the brain works when given with or without radiation therapy to other areas of the body in treating patients with extensive stage small cell lung cancer.
AB
Cross Cancer Institute, Edmonton
SK
Allan Blair Cancer Centre at Pasqua Hospital, Regina
3.Chemotherapy and Radiation in Treating Patients With Stage 3 Non-Small Cell Lung Cancer (PROCLAIM)
ClinicalTrials.gov Identifier: NCT00686959
Phase 3 Study of Pemetrexed, Cisplatin, and Radiotherapy Followed by Consolidation Pemetrexed Versus Etoposide, Cisplatin, and Radiotherapy Followed by Consolidation Cytotoxic Chemotherapy of Choice in Patients With Unresectable, Locally Advanced, Stage III Non-Small Cell Lung Cancer Other Than Predominantly Squamous Cell Histology
ON
Newmarket
Toronto
AB
Edmonton
QC
Montreal
4.Trial to Evaluate the Improvement in Lung Cancer Patients Receiving Radiation With or Without Brachytherapy (BRACHY)
ClinicalTrials.gov Identifier: NCT01351116
Purpose: A trial to improve the quality of life of patients with advanced non-small cell lung cancer (NSCLC) by evaluating the symptomatic improvements in lung cancer patients receiving external radiation with or without high dose internal radiation.
ON
Juravinski Cancer Center, Hamilton
5.Phase I/II Study of Fractionated Stereotactic Radiotherapy for Medically Inoperable Non-Small Cell Lung Cancer (NSCLC) or Metastatic Lung Tumours
ClinicalTrials.gov Identifier: NCT00351962
Purpose: Medically inoperable lung cancer or metastatic lung tumours will be treated with fractionated stereotactic radiation using a schedule of 1) 12 Gy x 4 treatments or 2) 6 Gy x 10 treatments.
AB
Tom Baker Cancer Center, Calgary
6. Cisplatin, Etoposide, and Two Different
Schedules of Radiation Therapy in Treating Patients With Limited Stage Small
Cell Lung Cancer
ClinicalTrials.gov Identifier: NCT00433563
RATIONALE: Drugs used in chemotherapy,
such as cisplatin and etoposide, work in different ways to stop the growth of tumor cells, either by killing the
cells or by stopping them from dividing. Radiation therapy uses high-energy
x-rays to kill tumor cells. It
is not yet known which schedule of radiation therapy is more effective when
given together with chemotherapy in treating small cell lung cancer.
PURPOSE: This randomized phase III
trial is studying two different schedules of radiation therapy to compare how
well they work when given together with cisplatin and etoposide in treating
patients with limited stage small cell lung
cancer
ON
Princess Margaret Hospital, Toronto
7. Stereotactic Body Radiation Therapy in
Treating Patients With Stage I Non-Small Cell Lung Cancer
ClinicalTrials.gov Identifier: NCT00750269
RATIONALE:
Stereotactic body radiation therapy may be able to send x-rays directly to the
tumour and cause less damage to normal tissue.
PURPOSE:
This phase I/II trial is studying the side effects and best dose of
stereotactic body radiation therapy and to see how well it works in treating
patients with stage I non-small cell lung cancer.
ON
Princess
Margaret Hospital, Toronto
8. Individual Boosting in Non-Small Cell
Lung Cancer Using Hypofraction, Intensity-modulated Radiation Therapy and
Respiratory Gating
ClinicalTrials.gov Identifier: NCT00690963
The purpose of this study is to determine
whether the combination of custom designed intensity-modulated radiotherapy
(based on individual tumoranatomy) with regular chepotherapy, will be safe enough to allow further
intensification of radiation treatment.
AB
Cross Cancer Institute, Edmonton
9. Stereotactic Radiation Therapy With or
Without Whole-Brain Radiation Therapy in Treating Patients With Brain
Metastases
ClinicalTrials.gov Identifier: NCT00377156
This randomized phase III trial is studying stereotactic radiation therapy
and whole-brain radiation therapy to see how well they work compared with
stereotactic radiation therapy alone in treating patients with brain
metastases.
AB
Tom Baker Cancer Center, Calgary
QC
CHUS-Hopital
Fleurimont, Sherbrooke
10. ShortNeoadjuvant Hemithoracic IMRT for MPM
ClinicalTrials.gov Identifier: NCT00797719
A Feasibility Study Evaluating Neoadjuvant
Hemithoracic Intensity Modulated Radiation Therapy for Surgically Resectable
Malignant Pleural Mesothelioma
ON
University Health Network, Toronto
11. Phase I/II Study of Fractionated
Stereotactic Radiotherapy for Early Stage Non-Small Cell Lung Cancer
ClinicalTrials.gov Identifier: NCT00888823
A new type of treatment called stereotactic radiotherapy has recently been
developed in hopes of improving the success of the treatment and improving the
convenience to patients, while reducing the side effects. This study is
developing stereotactic radiotherapy as a state-of-the-art treatment for lung
cancer patients.
AB
Tom
Baker Cancer Center, Calgary
Cross
Cancer Institute, Edmonton
12. Surgery
With or Without Internal Radiation Therapy Compared With Stereotactic Body
Radiation Therapy in Treating Patients With High-Risk Stage I Non-Small Cell
Lung Cancer
ClinicalTrials.gov Identifier: NCT01336894
This
randomized phase III trial is studying how well surgery with or without
internal radiation therapy works compared with stereotactic body radiation
therapy in treating patients with high-risk stage IA or stage IB non-small cell
lung cancer.
ON
London
Health Sciences Center
13. Radiation Therapy in Treating Patients
With Extensive Stage Small Cell Lung Cancer
ClinicalTrials.gov Identifier: NCT01055197
Randomized Phase II Study Comparing
Prophylactic Cranial Irradiation Alone to Prophylactic Cranial Irradiation and
Consolidative Extra-Cranial Irradiation for Extensive Disease Small Cell Lung
Cancer (ED-SCLC)
ON
London
Regional Cancer Center, London
Northeastern
Ontario Regional Cancer Center, Sudbury
Princess
Margaret Hospital, Toronto
SK
Allan
Blair Cancer Center, Regina