Second Line Trials
| ClinicalTrials.gov Identifier: |
NCT05899608 |
This study is currently recruiting participants.
This is a Phase 3 Randomized, Controlled, Multiregional Study of Ivonescimab Combined with Chemotherapy Versus Pembrolizumab Combined with Chemotherapy for the First-line Treatment of Metastatic Squamous Non-small Cell Lung Cancer. The primary endpoint is overall survival and key secondary endpoints include progression free survival. response and safety.
Ontario
University Health Network, Toronto
| ClinicalTrials.gov Identifier: |
NCT05647122 |
This study is currently recruiting participants.
This is a first-in-human (FIH) Phase I, multi-center, open-label, study of AZD9592, in patients with advanced solid tumors. The study consists of several study modules, each evaluating the safety, tolerability, preliminary efficacy, pharmacokinetics (PK), pharmacodynamics, anti-tumor activity, and immunogenicity of AZD9592, as monotherapy or in combination with anti-cancer agents.
Alberta
Edmonton
Ontario
Toronto
| ClinicalTrials.gov Identifier: |
NCT05118789 |
This study is currently recruiting participants.
Phase 1/2, dose escalation and expansion study designed to evaluate the safety and tolerability of NVL-520, determine the recommended phase 2 dose (RP2D), and evaluate the antitumor activity in patients with advanced ROS1-positive (ROS1+) NSCLC and other advanced ROS1-positive solid tumors.
Phase 1 will determine the RP2D and, if applicable, the maximum tolerated dose (MTD) of NVL-520 in patients with advanced ROS1-positive solid tumors.
Phase 2 will determine the objective response rate (ORR) as assessed by Blinded Independent Central Review (BICR) of NVL-520 at the RP2D. Secondary objectives will include the duration of response (DOR), time to response (TTR), progression-free survival (PFS), overall survival (OS), and clinical benefit rate (CBR) of NVL-520 in patients with advanced ROS1-positive NSCLC and other solid tumors.
Alberta
Cross Cancer Institute, Edmonton
Principal Investigator: Quincy Chu, MD
Ontario
Princess Margaret Cancer Research, Toronto
Principal Investigator: Geoffrey Liu, MD
| ClinicalTrials.gov Identifier: |
NCT04956640 |
This study is currently recruiting participants.
The purpose of this study is to find out whether the study drug, LY3537982, is safe and effective in cancer patients who have a specific genetic mutation (KRAS G12C). Patients must have already received or were not able to tolerate the standard of care, except for specific groups who have not had cancer treatment. The study will last up to approximately 4 years
Alberta
Cross Cancer Institute, Edmonton
Contact 855-569-6305
Ontario
Princess Margaret Hospital, Toronto
Contact 855-569-6305
| ClinicalTrials.gov Identifier: |
NCT04919811 |
This study is currently recruiting participants.
The main purpose of the study is to evaluate safety and efficacy of taletrectinib (also known as AB-106 or DS-6051b) monotherapy in the treatment of advanced NSCLC.
Ontario
Princess Margaret Cancer Centre, Toronto
Quebec
McGill University Health Centre Research Institute, Montréal
| ClinicalTrials.gov Identifier: |
NCT05094336 |
This study is currently recruiting participants.
The primary objective of Parts 1 and 2 of this study is to evaluate the safety, tolerability, and to determine the maximum tolerated dose (MTD) or recommended phase 2 dose (RP2D) of AMG 193 alone and in combination with docetaxel in adult participants with metastatic or locally advanced methylthioadenosine phosphorylase (MTAP)-null solid tumors.
The primary objective of Part 3 of this study is to evaluate the objective response rate (ORR) of AMG 193 in adult participants with metastatic or locally advanced MTAP-null solid tumors
Alberta
Cross Cancer Institute, Edmonton
Ontario
Princess Margaret Cancer Centre, Toronto
| ClinicalTrials.gov Identifier: |
NCT05384626 |
This study is currently recruiting participants.
Phase 1/2, dose escalation and expansion study designed to evaluate the safety and tolerability of NVL-655, determine the recommended phase 2 dose (RP2D), and evaluate the antitumor activity in patients with advanced ALK- positive (ALK+) NSCLC and other solid tumors.
Phase 1 will determine the RP2D and, if applicable, the MTD of NVL-655 in patients with advanced ALK+ solid tumors.
Phase 2 will determine the objective response rate (ORR) as assessed by Blinded Independent Central Review (BICR) of NVL-655 at the RP2D. Secondary objectives will include the duration of response (DOR), time to response (TTR), progression-free survival (PFS), overall survival (OS), and clinical benefit rate (CBR) of NVL-655 in patients with advanced ALK-positive NSCLC and other solid tumors.
Alberta
Cross Cancer Institute, Edmonton
Principal Investigator: Quincy Siu Chung Chu, MD
Ontario
Princess Margaret Cancer Centre, Toronto
Principal Investigator: Geoffrey Liu, M.D.
| ClinicalTrials.gov Identifier: |
NCT05221840 |
This study is currently recruiting participants.
This is a Phase III, randomised, double-blind, multicentre, international study assessing the efficacy and safety of durvalumab (MEDI4736) in combination with oleclumab (MEDI9447) or durvalumab (MEDI4736) with monalizumab (IPH2201) in adults with locally advanced (Stage III), unresectable NSCLC, who have not progressed following platinum-based cCRT.
Alberta
Edmonton
Ontario
Hamilton
Kingston
London
Toronto
| ClinicalTrials.gov Identifier: |
NCT04303780 |
This study is currently recruiting participants.
A Phase 3 Study to Compare AMG 510 with Docetaxel in Non Small Cell Lung Cancer (NSCLC) subjects with KRAS p. G12c mutation
Ontario
Hamilton
Ottawa
London
Toronto
| ClinicalTrials.gov Identifier: |
NCT04185883 |
This study is currently recruiting participants.
To evaluate the safety and tolerability of sotorasib administered in investigational regimens in adult participants with KRAS p.G12C mutant advanced solid tumors
Quebec
Laval
| ClinicalTrials.gov Identifier: |
NCT04606381 |
This study is currently recruiting participants.
The purpose of this study is to assess the feasibility of subcutaneous (SC) administration of amivantamab based on safety and pharmacokinetics and determine a dose, dose regimen and formulation for amivantamab SC delivery.
Ontario
University Health Network, Toronto
| ClinicalTrials.gov Identifier: |
NCT03645928 |
This study is currently recruiting participants.
A prospective, open-label, multi-cohort, non-randomized, multicenter Phase 2 study evaluating adoptive cell therapy (ACT) with TIL LN-144 (Lifileucel)/LN-145 in combination with checkpoint inhibitors or TIL LN-144 (Lifileucel)/LN-145/LN-145-S1 as a single agent therapy.
Ontario
Toronto
| ClinicalTrials.gov Identifier: |
NCT04589845 |
This study is currently recruiting participants.
TAPISTRY is a Phase II, global, multicenter, open-label, multi-cohort study designed to evaluate the safety and efficacy of targeted therapies or immunotherapy as single agents or in rational, specified combinations in participants with unresectable, locally advanced or metastatic solid tumors determined to harbor specific oncogenic genomic alterations or who are tumor mutational burden (TMB)-high as identified by a validated next-generation sequencing (NGS) assay. Participants with solid tumors will be treated with a drug or drug regimen tailored to their NGS assay results at screening. Participants will be assigned to the appropriate cohort based on their genetic alteration(s). Treatment will be assigned on the basis of relevant oncogenotype, will have cohort-specific inclusion/exclusion criteria, and, unless otherwise specified, will continue until disease progression, loss of clinical benefit, unacceptable toxicity, participant or physician decision to discontinue, or death, whichever occurs first.
British Colombia
Vancouver
Ontario
London
Ottawa
Toronto
Quebec
Montreal
| ClinicalTrials.gov Identifier: |
NCT03907852 |
This study is currently recruiting participants.
Gavocabtagene autoleucel (gavo-cel; TC-210) is a novel cell therapy that consists of autologous genetically engineered T cells expressing a single-domain antibody that recognizes human Mesothelin, fused to the CD3-epsilon subunit which, upon expression, is incorporated into the endogenous T cell receptor (TCR) complex.
This Phase 1/2 study aims to establish the recommended Phase 2 dose (RP2D) and subsequently evaluate the efficacy of gavo-cel, with and without immuno-oncology agents, in patients with advanced mesothelin-expressing cancers, with overall response rate and disease control rate as the primary Phase 2 endpoints.
Ontario
Toronto
| ClinicalTrials.gov Identifier: |
NCT04931654 |
This study is currently recruiting participants.
This is a Phase I/IIa study designed to evaluate if experimental anti-PD-1 and anti-TIM-3 bispecific antibody, AZD7789 is safe, tolerable and efficacious in participants with advanced solid tumors.
Ontario
Toronto
| ClinicalTrials.gov Identifier: |
NCT04084717 |
This study is currently active and recruiting participants
This is a phase 2 study of a drug called crizotinib in people with metastatic (the cancer has spread to other parts of the body) non-small cell lung cancer with a mutation (change) in genes called ROS1 or MET. The purpose of this study is to look at how effective crizotinib is at treating ROS1 or MET mutated non-small cell lung cancer.
Crizotinib, also called XALKORI, is a chemotherapy drug that is currently approved for the treatment of ALK- or ROS1- positive advanced non-small cell lung cancer.
Ontario
Princes Margaret Hospital, Toronto
| ClinicalTrials.gov Identifier: |
NCT03175224 |
This study is currently active and recruiting participants
The primary Phase 1 purpose of this study was to assess overall safety, tolerability and recommended Phase 2 dose (RP2D) of APL-101.
The Phase 2 portion will assess efficacy of the dose determined in Phase 1 in individuals with Non-Small Cell Lung Cancer with c-Met EXON 14 Skip Mutations; individuals with cancers associated with c-Met amplifications; individuals with cancers associated with c-Met fusion
Alberta
Edmonton
Manitoba
Winnipeg
Ontario
Toronto
Quebec
Montreal
| ClinicalTrials.gov Identifier: |
NCT03093116 |
This study is currently active and recruiting participants
Phase 1 dose escalation will determine the first cycle dose-limiting toxicities (DLTs), the maximum tolerated dose (MTD), the biologically effective dose and recommended Phase 2 dose (RP2D) of repotrectinib given to adult subjects with advanced solid malignancies harboring an ALK, ROS1, NTRK1, NTRK2, or NTRK3 gene rearrangement.
Midazolam DDI substudy will examine effect of of repotrectinib on CYP3A induction.
Phase 2 will determine the confirmed Overall Response Rate (ORR) as assessed by Blinded Independent Central Review (BICR) of repotrectinib in each subject population expansion cohort of advanced solid tumors that harbor a ROS1, NTRK1, NTRK2, or NTRK3 gene rearrangement. The secondary objective will include the duration of response (DOR), time to response (TTR), progression-free survival (PFS), overall survival (OS) and clinical benefit rate (CBR) of repotrectinib in each expansion cohort of advanced solid tumors that harbor a ROS1, NTRK1, NTRK2, or NTRK3 gene rearrangement.
Alberta
Edmonton
British Colombia
Vancouver
Ontario
Brampton
Ottawa
Toronto
| ClinicalTrials.gov Identifier: |
NCT02912949 |
This study is currently active and recruiting participants
This is a Phase I/II, open-label, multi-center, multi-national, dose escalation, single agent study to assess the safety, tolerability, PK, PD, immunogenicity and anti-tumor activity of zenocutuzumab (MCLA-128) in patients with solid tumors harboring an NRG1 fusion (eNRGy)
Ontario
Toronto
| ClinicalTrials.gov Identifier: |
NCT04449874 |
This study is currently active and recruiting participants
This is a Phase I dose-escalation and dose-expansion study that will evaluate the safety, pharmacokinetics (PK), and preliminary activity of GDC-6036 in patients with advanced or metastatic solid tumors with a KRAS G12C mutation.
Ontario
Ottawa
Toronto
Quebec
Montreal
| ClinicalTrials.gov Identifier: |
NCT04170946 |
This study is currently active and recruiting participants
This is a phase I, dose escalating study evaluating the safety of combining talazoparib and low dose consolidative thoracic radiotherapy for small cell lung cancer patients. This study will also determine the maximum tolerated dose (MTD) of talazoparib in combination with low dose thoracic radiotherapy.
Patients will start on talazoparib on day 1 of study intervention, and will continue to orally take talazoparib until the last day of radiation therapy. Up to 24 patients will be enrolled to the study, where the first 3 patients will start with a starting dose level of talazoparib is 0.5 mg PO once daily. This will increase to 1mg daily with each new cohort.
Ontario
Toronto
| ClinicalTrials.gov Identifier: |
NCT03178552 |
This study is currently recruiting participants.
This is a phase 2/3, global, multicenter, open-label, multi-cohort study designed to evaluate the safety and efficacy of targeted therapies or immunotherapy as single agents or in combination in participants with unresectable, advanced or metastatic NSCLC determined to harbor oncogenic somatic mutations or positive by tumor mutational burden (TMB) assay as identified by two blood-based next-generation sequencing (NGS) circulating tumor DNA (ctDNA) assays.
Alberta
Cross Cancer Institute, Edmonton
Ontario
Royal Victoria Regional Health Centre; c/o Oncology Clinical Trials, Barrie
William Osler Health System Brampton Civic Hospital, Brampton
London Health Sciences Centre · Victoria Hospital; Department of Medicine, London
Lakeridge Health Center; R. S. MacLaughlin Durham Regional Cancer Center, Oshawa
Sunnybrook Health Sciences Centre, Toronto
Princess Margaret Hospital; Medical Oncology Dept, Toronto
Quebec
Jewish General Hospital; Sir Mortimer B. Davis, Montreal
IUCPQ (Hôpital Laval), Quebec
Saskatchewan
Saskatoon Cancer Agency, Saskatoon
Manitoba
CancerCare Manitoba; Department of Medical Oncology, Winnipeg
| ClinicalTrials.gov Identifier: |
NCT04563338 |
This study is currently recruiting participants.
This study is being done to look at how effective the drug, atezolizumab, with or without the drug bevacizumab, is for people with inoperable liver cancer or non-small lung cancer that has spread to the liver. This will be done by looking at the duration of time from starting the study drug(s) until the cancer worsens in study participants.
This study will collect blood and tumor tissue samples from participants to look at changes to their tumor(s) before and after receiving atezolizumab and/or bevacizumab.
Ontario
Princess Margaret Cancer Centre, Toronto
| ClinicalTrials.gov Identifier: |
NCT03175224 |
This study is currently active and recruiting participants
The primary Phase 1 purpose of this study was to assess overall safety, tolerability and recommended Phase 2 dose (RP2D) of APL-101.
The Phase 2 portion will assess efficacy of the dose determined in Phase 1 in individuals with Non-Small Cell Lung Cancer with c-Met EXON 14 Skip Mutations; individuals with cancers associated with c-Met amplifications; individuals with cancers associated with c-Met fusion
Alberta
Cross Cancer Institute, Edmonton
Manitoba
CancerCare Manitoba, Winnipeg
Ontario
Princess Margaret Hospital, Toronto
Quebec
McGill University Health Center, Montreal
| ClinicalTrials.gov Identifier: |
NCT05067283 |
This study is currently recruiting participants.
This is a study evaluating the efficacy, safety, and pharmacokinetics of MK-1084 in participants with advanced solid tumors with identified kirsten rat sarcoma viral oncogene homolog G12C (KRASG12C) mutation and MK-1084 plus pembrolizumab in participants with first line (1L) non-small cell lung cancer (NSCLSC) with identified KRASG12C mutation.
Ontario
Hamilton Health Sciences, Juravinski Cancer Centre
Princess Margaret Cancer Centre, Toronto
| ClinicalTrials.gov Identifier: |
NCT04931654 |
This study is currently active and recruiting participants
This study (the SAVANNAH study) will investigate the efficacy of osimertinib in combination with savolitinib in patients with EGFRm+ and MET+, locally advanced or metastatic NSCLC who have progressed following treatment with osimertinib
Alberta
Calgary
Edmonton
Ontario
Newmarket
North York
Toronto
| ClinicalTrials.gov Identifier: |
NCT05364073 |
This study is currently active and recruiting participants
This is a Phase 1b, open-label, multi-center, dose-escalation and dose expansion study designed to evaluate the safety, pharmacokinetics (PK), and preliminary antitumor activity of furmonertinib in patients with advanced or metastatic non-small cell lung cancer (NSCLC) with activating, including uncommon, Epidermal Growth Factor Receptor (EGFR) or Human Epidermal Growth Factor Receptor 2 (HER2) mutations. Patients will be enrolled into one of 2 stages: Stage 1 (Dose Escalation and Backfill Cohorts) and Stage 2 (Dose Expansion).
Alberta
Edmonton
Ontario
Toronto
| ClinicalTrials.gov Identifier: |
NCT05241873 |
This study is currently active and recruiting participants
This is a Phase 1/2, open-label first-in-human study of the safety, pharmacokinetics (PK), pharmacodynamics, and anti-tumor activity of BLU-451 monotherapy and BLU-451 in combination with platinum-based chemotherapy (carboplatin and pemetrexed). All participants will receive BLU-451 on a 21-day treatment cycle.
Ontario
Princess Margaret Cancer Centre
| ClinicalTrials.gov Identifier: |
NCT04931654 |
This study is currently active and recruiting participants
This study will compare the clinical activity of novel regimens (in combination or as single agents) to SoC in participants with relapsed/refractory advanced NSCLC. The study will be conducted in two parts. Part 1 is an open-label, optional, non-randomized part based on safety and pharmacokinetics/pharmacodynamics (PK/PD) evaluation intended to generate additional data to qualify novel regimens for the randomized study. Part 2 is a randomized, Phase II open-label part comparing the efficacy and safety of these novel regimens with SoC. Drug name mentioned as GSK4428859A and EOS884448 are interchangeable for the same compound and will be referred to as GSK4428859A/EOS884448.
Alberta
Edmonton, Alberta, Canada, T6G 1Z2
Principal Investigator: Quincy Chu
Ontario
Brampton, Ontario, Canada, L6R 3J7
Principal Investigator: Parneet Cheema
Toronto, Ontario, Canada, M5G 2M9
Principal Investigator: Adrian Sacher
| ClinicalTrials.gov Identifier: |
NCT04335292 |
This study is currently recruiting participants.
This phase II single-armed study will examine the clinical utility of retreating patients with osimertinib, in the third-line, following first-line treatment with osimertinib and second-line treatment with platinum and pemetrexed chemotherapy. The current standard of care for first-line Epidermal Growth Factor Receptor (EGFR) mutated Advanced Non-Small Cell Lung Cancer (aNSCLC) is osimertinib, followed by cytotoxic chemotherapy.
The repeat of osimertinib following previous treatment failure is investigational, although supported by scientific rationale. The dosing and scheduling of osimertinib follows its use in approved settings. The investigators examine its tolerability and efficacy in this setting to ensure osimertinib is a safe third-line option for patients with Epidermal Growth Factor Receptor mutated (EGFR+) Advanced Non-Small Cell Lung Cancer(aNSCLC).
British Colombia
Vancouver
Ontario
Brampton
Hamilton
Kitchener
London
Oshawa
Ottawa
Toronto
| ClinicalTrials.gov Identifier: |
NCT05261399 |
This study is currently recruiting participants.
Clinical study to investigate the efficacy and safety of savolitinib in combination with osimertinib versus platinum-based doublet chemotherapy in participants with EGFR mutated, MET-overexpressed and/or amplified, locally advanced or metastatic NSCLC who have progressed on treatment with Osimertinib.
Ontario
Toronto
Quebec
Montreal
| ClinicalTrials.gov Identifier: |
NCT04862780 |
This study is currently recruiting participants.
This is a Phase 1/2, open-label, first-in-human (FIH) study designed to evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and anticancer activity of BLU-945, a selective EGFR inhibitor, as monotherapy or in combination with osimertinib.
Ontario
Princess Margaret Cancer Centre, Toronto
| ClinicalTrials.gov Identifier: |
NCT05388669 |
This study is active, but not recruiting participants.
The purpose of the study is to simplify amivantamab intravenous administration and to reduce dose times, by assessing a new formulation of amivantamab, amivantamab subcutaneous and co-formulated with recombinant human hyaluronidase (SC-CF), for subcutaneous administration. This formulation has the potential to enhance both the patient and physician experience with amivantamab by providing easier and accelerated administration.
Ontario
The Ottawa Hospital Cancer Centre, Ottawa
Princess Margaret Hospital, Toronto
| ClinicalTrials.gov Identifier: |
NCT02609776 |
This study is active, but not recruiting participants
The purpose of study is to evaluate the safety, pharmacokinetics, and preliminary efficacy of Amivantamab as a monotherapy and in combination with lazertinib, and to determine the recommended Phase 2 dose (RP2D) (monotherapy), recommended Phase 2 combination dose (RP2CD) (combination therapy), and to determine recommended Phase 2 Dose (RP2q3W) with combination chemotherapy (Amivantamab in combination with standard of care carboplatin and pemetrexed) in 21 day treatment cycle for participants with advanced non-small cell lung cancer (NSCLC).
British Columbia
Vancouver
Ontario
University Health Network, Toronto
| ClinicalTrials.gov Identifier: |
NCT04656652 |
This study is active but not currently recruiting.
This study will evaluate the efficacy, safety, and pharmacokinetics of DS-1062a versus docetaxel in participants with previously treated advanced or metastatic non-small cell lung cancer (NSCLC) with or without actionable genomic alterations.
Alberta
Edmonton
Ontario
University Health Network, Toronto
Sunnybrtook Health Sciences Centre, Toronto
Quebec
Montreal
| ClinicalTrials.gov Identifier: |
NCT02785952 |
This study is active but not currently recruiting.
This randomized phase III trial compares nivolumab with ipilimumab and nivolumab alone in treating patients with stage IV squamous cell lung cancer that has come back after previous treatment. This is a "non-match" sub-study that includes all screened patients not eligible for a biomarker-driven sub-study. Monoclonal antibodies, such as nivolumab and ipilimumab, may be able to shrink tumours. It is not yet known whether nivolumab works better with or without ipilimumab in treating patients with squamous cell lung cancer.
Ontario
University Health Network-Princess Margaret Hospital, Toronto
Saskatchewan
Allan Blair Cancer Centre, Regina
Saskatoon Cancer Centre, Saskatoon
| ClinicalTrials.gov Identifier: |
NCT03539536 |
This study is active but not currently recruiting.
This study is designed to identify the target Non-Small Cell Lung Cancer (NSCLC) population(s) that over express c-Met (c-Met+) best suited for telisotuzumab vedotin therapy in the second line or third line setting (Stage 1) and then to expand the group(s) to further evaluate efficacy in the selected population(s) (Stage 2).
Alberta
Cross Cancer Institute / ID# 204540, Edmonton
Ontario
The Ottawa Hospital / ID# 205579, Ottawa
Princess Margaret Cancer Centre, Toronto
Quebec
CISSS de la Monteregie / ID# 211356, Greenfield Park
| ClinicalTrials.gov Identifier: |
NCT03334617 |
This study is active but not currently recruiting.
This is an open-label, multi-centre, umbrella Phase II study in patients with metastatic NSCLC who have progressed on an anti-PD-1/PD-L1 containing therapy. This study is modular in design, allowing initial assessment of the efficacy, safety, and tolerability of multiple treatment arms.
Alberta
Edmonton
Ontario
Brampton
Ottawa
Toronto
Quebec
Montreal
| ClinicalTrials.gov Identifier: |
NCT04938817 |
This study is active but not recruiting participants
This study is a rolling arm study of pembrolizumab in combination with investigational agents in participants with anti-programmed cell death 1 (PD-1)/ programmed cell death ligand 1 (PD-L1) refractory ES-SCLC in need of second-line treatment. This study will have 2 parts: an initial safety lead-in to determine safety and tolerability for experimental combinations of investigational agents without an established recommended phase 2 dose (RP2D) followed by an efficacy evaluation.
Investigational agents will initiate directly in or be added to the efficacy evaluation after an initial evaluation of safety and tolerability of the investigational agent has been completed in a separate study or in the safety lead-in of this study. If an RP2D for a combination being evaluated in the safety lead-in is established from another study, then the efficacy evaluation may begin at the determined RP2D.
There will be no hypothesis testing in this study.
Alberta
Edmonton
Ontario
Toronto
Quebec
Montreal
| ClinicalTrials.gov Identifier: |
NCT05712902 |
This study is active but not recruiting participants
This is a Phase II, single-arm, multi-center clinical study to evaluate the anti-tumor efficacy, safety, tolerability and pharmacokinetics of DZD9008 in participants with locally advanced or metastatic NSCLC carrying EGFR exon 20 insertion mutations whose disease has progressed on prior platinum-based chemotherapy
Ontario
Princess Margaret Cancer Centre