Radiotherapy Trials

1. Cisplatin, Etoposide, and Two Different Schedules of Radiation Therapy in Treating Patients With Limited Stage Small Cell Lung Cancer

       ClinicalTrials.gov Identifier:               NCT00433563       
 
This study is ongoing, but not recruiting participants
 
RATIONALE: Drugs used in chemotherapy, such as cisplatin and etoposide, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Radiation therapy uses high-energy x-rays to kill tumor cells. It is not yet known which schedule of radiation therapy is more effective when given together with chemotherapy in treating small cell lung cancer.
 
PURPOSE: This randomized phase III trial is studying two different schedules of radiation therapy to compare how well they work when given together with cisplatin and etoposide in treating patients with limited stage small cell lung cancer
 
Ontario 
Princess Margaret Hospital, Toronto
 

2. Individual Boosting in Non-Small Cell Lung Cancer Using Hypofraction, Intensity-modulated Radiation Therapy and Respiratory Gating

 
      ClinicalTrials.gov Identifier:             NCT00690963      
 
This study is ongoing, but not recruiting participants.

 
The purpose of this study is to determine whether the combination of custom designed intensity-modulated radiotherapy (based on individual tumor anatomy) with regular chepotherapy, will be safe enough to allow further intensification of radiation treatment.
 
Alberta
Cross Cancer Institute, Edmonton
 

3. Short  Neoadjuvant Hemithoracic IMRT for MPM

      ClinicalTrials.gov Identifier:             NCT00797719      

 
A Feasibility Study Evaluating Neoadjuvant Hemithoracic Intensity Modulated Radiation Therapy for Surgically Resectable Malignant Pleural Mesothelioma.
 
Ontario
University Health Network, Toronto
 

4. Pilot Project of Adaptive Thoracic Radiotherapy for Small Cell Lung Cancer

      ClinicalTrials.gov Identifier:             NCT01426841      

This study is ongoing, but not recruiting participants.
 
This study is intended to assess the feasibility of adjusting a radiation plan during its course to accommodate for a shrinking tumour target. The investigators hypothesize that an adaptive radiotherapy (RT) planning strategy for small cell lung cancer (SCLC) patients with chest-confined disease will allow for safe delivery of higher doses of chest RT than a non-adaptive RT planning approach without subjecting normal critical structures to unacceptable doses of radiotherapy.
 
Alberta
Cross Cancer Institute
 

5. Stereotactic Body Radiotherapy Versus Conventional Radiotherapy in Medically-Inoperable Non-Small Lung Cancer Patients (LUSTRE)

      ClinicalTrials.gov Identifier:              NCT01968941      

 
A Randomized Trial of Medically-Inoperable Stage 1 Non-small Cell Lung Cancer Patients Comparing Stereotactic Body Radiotherapy Versus Conventional Radiotherapy.
 
Ontario
Juravinski Hospital Cancer Center, Hamilton
       
Niagara Health System-Walker Family Cancer Centre
St. Catharines, Ontario
 
British Columbia 
BCCA Vancouver Island Cancer Centre
Victoria, British Columbia
 
Alberta
Tom Baker Cancer Centre
Calgary
 
Manitoba
Cancer Care Manitoba
Winnipeg, Manitoba
 
Quebec 
CHUM Hospital Notre Dame
Montreal, Quebec
 
Hôpital Maisonneuve-Rosemont
Montreal, Quebec
 
Montreal General Hospital McGill
Montreal, Quebec
 
Saskatchewan
Saskatoon Cancer Centre
Saskatoon, Saskatchewan
 

6. Stereotactic Radiotherapy (SBRT) of Lung Metastasis

      ClinicalTrials.gov Identifier:             NCT01803542      

 
The purpose of this institutional protocol is to offer SBRT to selected patients in a controlled environment to refine treatment techniques (including dose/fractionation schedules) and standardize follow-up.
 
Ontario 
Princess Margaret Hospital, University Health Network
Toronto
 

7. Observing Patients With Palliative Asymptomatic Centrally Located Advanced Non-small Cell Lung Carcinoma (NSCLC)

      ClinicalTrials.gov Identifier:             NCT01279408      

 
The aim of the study is to assess current practice within PROP &lung teams, for treating asymptomatic patients with centrally located non-small cell lung cancer (NSCLC), and to observe outcomes for those patients receiving immediate or deferred RT. This is a prospective cohort trial. Patients will be managed by immediate radiotherapy (RT) or a deferred approach according to physicians' individual current clinical practice.
 
Ontario 
University Health Network
Toronto
 

8. Functional Lung Avoidance for Individualized Radiotherapy (FLAIR): A Randomized, Double-Blind Clinical Trial

      ClinicalTrials.gov Identifier:             NCT02002052      

 
Functional lung avoidance radiotherapy aims to reduce radiotherapy dose to regions of functioning lung, instead depositing dose in areas of lung that are not well-ventilated.
 
Ontario 
London Health Sciences Center
London

9. A Phase II Trial Measuring the Integration of Stereotactic Radiotherapy Plus Surgery in Early Non-Small Cell Lung Cancer

      ClinicalTrials.gov Identifier:             NCT02136355      

 
Stereotactic ablative radiotherapy (SABR) is a new radiation treatment that delivers high-dose, precise radiation to small tumors in 1-3 weeks of treatment.
 
The study combines SABR and surgery to treat non-small cell lung cancer. SABR will be done first, with surgery done approximately 10 weeks later. There will be some extra imaging done before and after the SABR.
 
The purpose of this study is to determine how effective SABR is in killing the cancer cells, and if SABR can help make surgery more effective.
 
Ontario 
London Regional Cancer Program of the Lawson Health Research Institute
 

10. Locally Invasive NSCLC Treated With NEo-Adjuvant Stereotactic Body RadioTherapy and REsection (LINNEARRE-I)

       ClinicalTrials.gov Identifier:            NCT02433574      
 
This is a phase I study that investigates the feasibility and safety of delivering Stereotactic Body Radiotherapy (SBRT) to patients with locally invasive NSCLC (cT3-4, N0-1) who are at risk for incomplete resection.
 
Twenty patients with NSCLC will be treated with SBRT followed by surgery and appropriate adjuvant therapy. Patients will be divided into groups, of 5 patients each, treated with escalating doses (35, 40, 45 and 50 Gy) in 10 daily fractions.
 
The primary outcome is the feasibility i.e. the ability to complete safely SBRT and surgery (within 6 weeks). Secondary outcomes include acute and late adverse events, R0/R1/R2 rates and secondary surrogates of feasibility. If successful, this study will lead to further evaluation of pre-operative SBRT in NSCLC.
 
Ontario 
Juravinski Cancer Center
Hamilton 
 

11. Stereotactic Body Radiotherapy (RT) for Non-Small Cell Lung Cancer

      ClinicalTrials.gov Identifier:            NCT01480973      

 
SBRT involves highly precise delivery of very high dose Radiotherapy (RT) over a very few fractions (hypofractionation) to accurately describe, size-restricted malignant targets in which motion has been accounted for during the delivery process. SBRT administration achieves avoidance of normal tissue exposure to radiation during the planning process, by providing for sharp fall-off dose gradients outside the target.
 
Ontario
University Health Network, Toronto
 

12. Stereotactic Radiotherapy for Oligo-Progressive Non-Small Cell Lung Cancer (STOP-NSCLC)

      ClinicalTrials.gov Identifier:              NCT02756793      

 
A multicenter randomized phase II trial of stereotactic body radiotherapy for oligo-progressive non-small cell lung cancer. Eligible patients will be randomized in a 1:2 ratio between receiving their standard of care therapy or stereotactic ablative radiotherapy (SABR) to all sites of oligo-progressive lesions. Radiotherapy will be administered as soon as possible following randomization, and subjects will be followed until next disease progression. The primary outcome is progression-free survival (PFS).
 
British Columbia 
BC Cancer Agency Fraser Valley
Surrey,  V3V 1Z2
 
Ontario 
London Regional Cancer Program
London, Ontario,  N6A 4L6
 

13. Assessing the Efficacy and Safety of Selective Metabolically Adaptive Radiation Dose Escalation in Locally Advanced Non-Small Cell Lung Cancer Receiving Definitive Chemoradiotherapy (PET-BOOST)

      ClinicalTrials.gov Identifier:             NCT02788461      
 
A randomized phase II trial to assess the efficacy and safety of selective metabolically adaptive radiation dose escalation in locally advanced non-small cell lung cancer receiving definitive chemoradiotherapy. Eligible and consenting patients will be randomized to receive conventional chemoradiotherapy or chemoradiotherapy with a radiation (RT) integrated boost. All patients will receive a fludeoxyglucose-positron emission tomography (FDG-PET) scan within two weeks prior to starting treatment. The primary outcome is to determine if dose escalation to metabolically active tumour subvolumes will reduce local-regional failure rate at 2 years.
 
Ontario 
London Regional Cancer Program
London,  N6A 4L6
 
Princess Margaret Cancer Centre
Toronto, M5G 2M9
 

14. Phase II Trial of Individualized Lung Tumour Stereotactic Ablative Radiotherapy (iSABR)

      ClinicalTrials.gov Identifier:             NCT01463423     

 
A research study using a method of treating lug cancer with focused radiation called Stereotactic Ablative Radiotherapy (SABR). The purpose of this study is to evaluate the effectiveness of individualizing the dose of radiation used to treat lung tumours with SABR based on tumour-specific factors.
 
Ontario 
Princess Margaret Cancer Center
 

15. Whole-Brain Radiation Therapy With or Without Hippocampal Avoidance in Treating Patients With Limited Stage or Extensive Stage Small Cell Lung Cancer

      ClinicalTrials.gov Identifier:              NCT02635009      

 
This randomized phase II/III trial studies how well whole-brain radiation therapy works and compares it with or without hippocampal avoidance in treating patients with small cell lung cancer that is found in one lung, the tissues between the lungs, and nearby lymph nodes only (limited stage) or has spread outside of the lung in which it began or to other parts of the body (extensive stage). Radiation therapy uses high energy x-rays to kill tumour cells and shrink tumours. The hippocampus is part of the brain that is important for memory. Avoiding the hippocampus during whole-brain radiation could decrease the chance of side effects on memory and thinking. It is not yet known whether giving whole-brain radiation therapy is more effective with or without hippocampal avoidance in treating patients with small cell lung cancer.
 
Quebec 
CHU de Quebec-L'Hotel-Dieu de Quebec (HDQ)
Quebec City,  G1R 2J6
 

16. JoLT-Ca Sublobar Resection (SR) Versus Stereotactic Ablative Radiotherapy (SAbR) forLung Cancer (STABLE-MATES)

      ClinicalTrials.gov Identifier:             NCT02468024      

 
JoLT-Ca A Randomized Phase III Study of Sublobar Resection (SR) Versus Stereotactic Ablative Radiotherapy (SAbR) in High Risk Patients With Stage I Non-Small Cell Lung Cancer (NSCLC), The STABLE-MATES Trial.
 
Quebec 
CHUM
Montréal, Quebec, 26214

 

17. Effect of Tumor Treating Fields (TTFields) (150 kHz) Concurrent With Standard of Care Therapies for Treatment of Stage 4 Non-small Cell Lung Cancer (NSCLC) Following Platinum Failure (LUNAR)

 
      ClinicalTrials.gov Identifier:             NCT02973789      

 
The study is a prospective, randomized controlled phase III trial aimed to test the efficacy and safety of TTFields, using the NovoTTF-100L System, concurrent with standard therapies for stage 4 NSCLC patients, following progression while on or after platinum based treatment.The device is an experimental, portable, battery operated device for chronic administration of alternating electric fields (termed TTFields or TTF) to the region of the malignant tumor, by means of surface, insulated electrode arrays.
 
Quebec
McGill University Health Centre                                                                                   Recruiting 
Montréal, Quebec, Canada, H4A 3J1
Contact: Nicola Raby, 514-934-1934 ext. 34095   
nicola.raby@muhc.mcgill.ca   
Principal Investigator: Scott Owen, MD         

Centre intégré universitaire de santé et de services sociaux de l'Estrie –
Centre Hospitalier Universitaire de Sherbrooke (CIUSSS de l'Estrie - CHUS)               Recruiting 
Sherbrooke, Quebec, Canada, J1H 5N4
Contact: Anick Champoux, RN
819-346-1110 ext. 12811   
anick.champoux.ciussse-chus@ssss.gouv.qc.ca   
Principal Investigator: Nicole Bouchard, MD         

Saskatchewan 
Allan Blair Cancer Center                                                                                             Recruiting                                    
Regina, Saskatchewan, Canada, S4T 7T1
Contact: Wendie Templeton, CCRP
306-766-2488   
wendie.templeton@saskcancer.ca   
Principal Investigator: Mussawar Iqbal, MD