Radiotherapy Trials

1. Talazoparib and Thoracic RT for ES-SCLC

       ClinicalTrials.gov Identifier:               NCT04170946       
 
This study is currently recruiting participants
 
This is a phase I, dose escalating study evaluating the safety of combining talazoparib and low dose consolidative thoracic radiotherapy for small cell lung cancer patients. This study will also determine the maximum tolerated dose (MTD) of talazoparib in combination with low dose thoracic radiotherapy.

Patients will start on talazoparib on day 1 of study intervention, and will continue to orally take talazoparib until the last day of radiation therapy. Up to 24 patients will be enrolled to the study, where the first 3 patients will start with a starting dose level of talazoparib is 0.5 mg PO once daily. This will increase to 1mg daily with each new cohort.
 
Ontario
Princess Margaret Hospital, Toronto
 

2. Individual Boosting in Non-Small Cell Lung Cancer Using Hypofraction, Intensity-modulated Radiation Therapy and Respiratory Gating

 
      ClinicalTrials.gov Identifier:             NCT00690963      
 
This study's status is unknown.
 
The purpose of this study is to determine whether the combination of custom designed intensity-modulated radiotherapy (based on individual tumor anatomy) with regular chepotherapy, will be safe enough to allow further intensification of radiation treatment.
 
Alberta
Cross Cancer Institute, Edmonton
 

3. Short  Neoadjuvant Hemithoracic IMRT for MPM

      ClinicalTrials.gov Identifier:             NCT00797719      

This study is currently recruiting participants
 
A Feasibility Study Evaluating Neoadjuvant Hemithoracic Intensity Modulated Radiation Therapy for Surgically Resectable Malignant Pleural Mesothelioma.
 
Ontario
University Health Network, Toronto
 

4. Pilot Project of Adaptive Thoracic Radiotherapy for Small Cell Lung Cancer

      ClinicalTrials.gov Identifier:             NCT01426841      

This study's status is unknown.
 
This study is intended to assess the feasibility of adjusting a radiation plan during its course to accommodate for a shrinking tumour target. The investigators hypothesize that an adaptive radiotherapy (RT) planning strategy for small cell lung cancer (SCLC) patients with chest-confined disease will allow for safe delivery of higher doses of chest RT than a non-adaptive RT planning approach without subjecting normal critical structures to unacceptable doses of radiotherapy.
 
Alberta
Cross Cancer Institute
 

5. Stereotactic Body Radiotherapy Versus Conventional Radiotherapy in Medically-Inoperable Non-Small Lung Cancer Patients (LUSTRE)

      ClinicalTrials.gov Identifier:              NCT01968941      

This study is active, but not recruiting participants
 
A Randomized Trial of Medically-Inoperable Stage 1 Non-small Cell Lung Cancer Patients Comparing Stereotactic Body Radiotherapy Versus Conventional Radiotherapy.
 
Ontario
Juravinski Hospital Cancer Center, Hamilton       
Niagara Health System-Walker Family Cancer Centre, St. Catharines
 
British Columbia 
BCCA Vancouver Island Cancer Centre, Victoria
 
Alberta
Tom Baker Cancer Centre, Calgary
 
Manitoba
Cancer Care Manitoba, Winnipeg
 
Quebec 
CHUM Hospital Notre Dame, Montreal
Hôpital Maisonneuve-Rosemont, Montreal
Montreal General Hospital McGill, Montreal
 
Saskatchewan
Saskatoon Cancer Centre, Saskatoon

6. Stereotactic Radiotherapy (SBRT) of Lung Metastasis

      ClinicalTrials.gov Identifier:             NCT01803542      

This study is currently recruiting participants
 
The purpose of this institutional protocol is to offer SBRT to selected patients in a controlled environment to refine treatment techniques (including dose/fractionation schedules) and standardize follow-up.
 
Ontario 
Princess Margaret Hospital, University Health Network, Toronto

7. Observing Patients With Palliative Asymptomatic Centrally Located Advanced Non-small Cell Lung Carcinoma (NSCLC)

      ClinicalTrials.gov Identifier:             NCT01279408      

This study is ongoing, but not recruiting participants
 
The aim of the study is to assess current practice within PROP &lung teams, for treating asymptomatic patients with centrally located non-small cell lung cancer (NSCLC), and to observe outcomes for those patients receiving immediate or deferred RT. This is a prospective cohort trial. Patients will be managed by immediate radiotherapy (RT) or a deferred approach according to physicians' individual current clinical practice.
 
Ontario 
University Health Network, Toronto
 

8. Palliative Thoracic ImmunoRT

      ClinicalTrials.gov Identifier:             NCT03705806      

This study is currently recruiting participants
 
The trial is designed as a prospective observational single arm study investigating stage IV non-small cell lung cancer patients who are routinely treated with a PD-1 inhibitor for indications approved by Health Canada. All patients who are selected will be referred for palliative thoracic radiotherapy and treated with a standard dose prescription of 30 Gy in 10 fractions.
 
Ontario
University Health Network, Princess Margaret Cancer Centre

9. A Phase II Trial Measuring the Integration of Stereotactic Radiotherapy Plus Surgery in Early Non-Small Cell Lung Cancer

      ClinicalTrials.gov Identifier:             NCT02136355      

This study is active, but not recruiting participants
 
Stereotactic ablative radiotherapy (SABR) is a new radiation treatment that delivers high-dose, precise radiation to small tumors in 1-3 weeks of treatment.
 
The study combines SABR and surgery to treat non-small cell lung cancer. SABR will be done first, with surgery done approximately 10 weeks later. There will be some extra imaging done before and after the SABR.
 
The purpose of this study is to determine how effective SABR is in killing the cancer cells, and if SABR can help make surgery more effective.
 
Ontario 
London Regional Cancer Program of the Lawson Health Research Institute
 

10. Locally Invasive NSCLC Treated With NEo-Adjuvant Stereotactic Body RadioTherapy and REsection (LINNEARRE-I)

       ClinicalTrials.gov Identifier:            NCT02433574      

This study's status is unknown.
 
This is a phase I study that investigates the feasibility and safety of delivering Stereotactic Body Radiotherapy (SBRT) to patients with locally invasive NSCLC (cT3-4, N0-1) who are at risk for incomplete resection.
 
Twenty patients with NSCLC will be treated with SBRT followed by surgery and appropriate adjuvant therapy. Patients will be divided into groups, of 5 patients each, treated with escalating doses (35, 40, 45 and 50 Gy) in 10 daily fractions.
 
The primary outcome is the feasibility i.e. the ability to complete safely SBRT and surgery (within 6 weeks). Secondary outcomes include acute and late adverse events, R0/R1/R2 rates and secondary surrogates of feasibility. If successful, this study will lead to further evaluation of pre-operative SBRT in NSCLC.
 
Ontario 
Juravinski Cancer Center, Hamilton 

11. Sequencing of Stereotactic Ablative Body Radiotherapy in Combination With PD-1 Blockade Using Pembrolizumab in Metastatic Non-Small Cell Lung Carcinoma (SABRseq)

      ClinicalTrials.gov Identifier:            NCT03307759      

This study is currently recruiting participants
 
This investigator driven Phase Ib study will examine the safety, efficacy and biological effects of two schedules of pembrolizumab, an antibody targeted against anti-programmed cell death 1 (PD-1), which will be given either before or after stereotactic ablative body radiotherapy (SABR) for metastatic NSCLC.
 
Ontario
London Hospital, London
 

12. Stereotactic Radiotherapy for Oligo-Progressive Metastatic Cancer (The STOP Trial)

      ClinicalTrials.gov Identifier:              NCT02756793      

This study is currently recruiting participants
 
A multicenter randomized phase II trial of stereotactic body radiotherapy for oligo-progressive non-small cell lung cancer. Eligible patients will be randomized in a 1:2 ratio between receiving their standard of care therapy or stereotactic ablative radiotherapy (SABR) to all sites of oligo-progressive lesions. Radiotherapy will be administered as soon as possible following randomization, and subjects will be followed until next disease progression. The primary outcome is progression-free survival (PFS).
 
British Columbia 
BC Cancer Agency Fraser Valley, Surrey
 
Ontario 
London Regional Cancer Program, London

13. Assessing the Efficacy and Safety of Selective Metabolically Adaptive Radiation Dose Escalation in Locally Advanced Non-Small Cell Lung Cancer Receiving Definitive Chemoradiotherapy (PET-BOOST)

      ClinicalTrials.gov Identifier:             NCT02788461      
 
This study is currently recruiting participants
 
A randomized phase II trial to assess the efficacy and safety of selective metabolically adaptive radiation dose escalation in locally advanced non-small cell lung cancer receiving definitive chemoradiotherapy. Eligible and consenting patients will be randomized to receive conventional chemoradiotherapy or chemoradiotherapy with a radiation (RT) integrated boost. All patients will receive a fludeoxyglucose-positron emission tomography (FDG-PET) scan within two weeks prior to starting treatment. The primary outcome is to determine if dose escalation to metabolically active tumour subvolumes will reduce local-regional failure rate at 2 years.
 
Ontario 
London Regional Cancer Program, London
Princess Margaret Cancer Centre, Toronto

14. Phase II Trial of Individualized Lung Tumour Stereotactic Ablative Radiotherapy (iSABR)

      ClinicalTrials.gov Identifier:             NCT01463423     

This study is active, but not recruiting participants
 
A research study using a method of treating lug cancer with focused radiation called Stereotactic Ablative Radiotherapy (SABR). The purpose of this study is to evaluate the effectiveness of individualizing the dose of radiation used to treat lung tumours with SABR based on tumour-specific factors.
 
Ontario 
Princess Margaret Cancer Center
 

15. Whole-Brain Radiation Therapy With or Without Hippocampal Avoidance in Treating Patients With Limited Stage or Extensive Stage Small Cell Lung Cancer

      ClinicalTrials.gov Identifier:              NCT02635009      

This study is currently recruiting participants
 
This randomized phase II/III trial studies how well whole-brain radiation therapy works and compares it with or without hippocampal avoidance in treating patients with small cell lung cancer that is found in one lung, the tissues between the lungs, and nearby lymph nodes only (limited stage) or has spread outside of the lung in which it began or to other parts of the body (extensive stage). Radiation therapy uses high energy x-rays to kill tumour cells and shrink tumours. The hippocampus is part of the brain that is important for memory. Avoiding the hippocampus during whole-brain radiation could decrease the chance of side effects on memory and thinking. It is not yet known whether giving whole-brain radiation therapy is more effective with or without hippocampal avoidance in treating patients with small cell lung cancer.
 
Quebec 
CHU de Quebec-L'Hotel-Dieu de Quebec (HDQ), Quebec City

16. JoLT-Ca Sublobar Resection (SR) Versus Stereotactic Ablative Radiotherapy (SAbR) forLung Cancer (STABLE-MATES)

      ClinicalTrials.gov Identifier:             NCT02468024      

This study is currently recruiting participants
 
JoLT-Ca A Randomized Phase III Study of Sublobar Resection (SR) Versus Stereotactic Ablative Radiotherapy (SAbR) in High Risk Patients With Stage I Non-Small Cell Lung Cancer (NSCLC), The STABLE-MATES Trial.
 
Quebec 
CHUM, Montréal

17. Effect of Tumor Treating Fields (TTFields) (150 kHz) Concurrent With Standard of Care Therapies for Treatment of Stage 4 Non-small Cell Lung Cancer (NSCLC) Following Platinum Failure (LUNAR)

 
      ClinicalTrials.gov Identifier:             NCT02973789      

This study is currently recruiting participants
 
The study is a prospective, randomized controlled phase III trial aimed to test the efficacy and safety of TTFields, using the NovoTTF-100L System, concurrent with standard therapies for stage 4 NSCLC patients, following progression while on or after platinum based treatment.The device is an experimental, portable, battery operated device for chronic administration of alternating electric fields (termed TTFields or TTF) to the region of the malignant tumor, by means of surface, insulated electrode arrays.
 
Quebec
McGill University Health Centre                                                                                    
Montréal, QC,  H4A 3J1
Contact: Nicola Raby, 514-934-1934 ext. 34095   
nicola.raby@muhc.mcgill.ca   
Principal Investigator: Scott Owen, MD         

Centre intégré universitaire de santé et de services sociaux de l'Estrie –
Centre Hospitalier Universitaire de Sherbrooke (CIUSSS de l'Estrie - CHUS)                
Sherbrooke, QC,  J1H 5N4
Contact: Anick Champoux, RN
819-346-1110 ext. 12811   
anick.champoux.ciussse-chus@ssss.gouv.qc.ca   
Principal Investigator: Nicole Bouchard, MD         

Saskatchewan 
Allan Blair Cancer Center                                                                                                                                 
Regina, SK,  S4T 7T1
Contact: Wendie Templeton, CCRP
306-766-2488   
wendie.templeton@saskcancer.ca   
Principal Investigator: Mussawar Iqbal, MD

18. Calypso Guided High Precision Stereotactic Ablative Radiosurgery for Lung Tumours Using Real-Time Tumour Tracking & Respiratory Gating (GPS)

      ClinicalTrials.gov Identifier:             NCT03322072    

This study is currently recruiting participants
 

This is a single arm seamless phase I/II prospective cohort study. Patients with early stage Non-Small Cell Lung Cancer (T1-T2N0M0) or those with a single pulmonary metastasis of a known malignancy (either following radical treatment or systemic therapy) will be offered participation in this study. Participants will have three tumor locator beacons placed with a flexible bronchoscope in the small bronchial airways in proximity (<3cm) from their lung tumors. These tumor locator beacons will provide real-time positional data and will allow for smaller treatment volumes of Stereotactic Ablative Radiosurgery (SABR) and also allow for a specialized form of treatment delivery known as respiratory gated SABR. This is expected to result in higher precision radiotherapy delivery with less radiotherapy dose to healthy tissues which are in close proximity to the lung tumours.

 

Manitoba

CancerCare Manitoba, Winnipeg
 

19. Efficacy and Safety Study of Stereotactic Body Radiotherapy (SBRT) With or Without Pembrolizumab (MK-3475) in Adults With Medically Inoperable Stage I or IIA Non-Small Cell Lung Cancer (NSCLC) (MK-3475-867/KEYNOTE-867)


      ClinicalTrials.gov Identifier:             NCT03924869     

This study is currently recruiting participants
 

The purpose of this study is to assess the efficacy and safety of stereotactic body radiotherapy (SBRT) plus pembrolizumab (MK-3475) in the treatment of adult participants with medically inoperable Stage I or IIA non-small cell lung cancer (NSCLC).


New Brunswick 

Moncton

Ontario

Kingston

Mississauga

Ottawa

Sault Ste. Marie

Sudbury

Quebec

Montreal, QC

Sherbrooke, QC
 

20. SUNSET: SBRT for Ultra-central NSCLC- a Safety and Efficacy Trial

 
      ClinicalTrials.gov Identifier:             NCT03306680    

This study is currently recruiting participants
 
This multi-centre phase I dose-escalation study will use a time-to-event continual reassessment method (TIT-CRM).

Accrual will start at level 1 (60 Gy in 8 fractions). Patients will be assigned to treatment doses using the TITE-CRM model. The model will use all available information from previously accrued patients to assign the highest dose with a predicted risk of grade 3 toxicity of 30% or less.
 
British Columbia
BC Cancer -Vancouver Island
 
Ontario
London Regional Cancer Program
Princess Margaret Cancer Centre
 
Quebec
Centre Hospitalier de l'Universite de Montreal (CHUM)
McGill University Health Centre-Cedars Cancer Centre
 
Saskatchewan
Saskatoon Cancer Centre

21. Durvalumab vs Placebo With Stereotactic Body Radiation Therapy in Early Stage Unresected Non-small Cell Lung Cancer Patients (PACIFIC-4)
 
      ClinicalTrials.gov Identifier:             NCT03833154    
 
This study is currently recruiting participants
 
This is a Phase III, randomized, placebo-controlled, double-blind, multi-center study assessing the efficacy and safety of durvalumab with SoC SBRT versus placebo with SoC SBRT in patients with unresected clinical Stage I/II lymph node-negative (T1 to T3N0M0) NSCLC.
 
AB
Calgary
Edmonton
 
ON
London
Toronto
 
QC
Montreal
 

22. M7824 With cCRT in Unresectable Stage III Non-small Cell Lung Cancer (NSCLC)

      ClinicalTrials.gov Identifier:             NCT03840902    

This study is currently recruiting participants
 
The main purpose of this study is to evaluate safety and efficacy in participants treated with concomitant chemoradiation therapy (cCRT) plus M7824 followed by M7824 compared to cCRT plus placebo followed by durvalumab.
 
British Columbia
BC Cancer Agency Center for the Southern Interior, Kelowna