Surgery Trials

1. A Phase III Randomized Trial of Lobectomy Versus Sublobar Resection for Small (≤ 2 CM) Peripheral Non-Small Cell Lung Cancer

      ClinicalTrials.gov Identifier:             NCT00499330      

 
RATIONALE: Wedge resection or segmentectomy may be less invasive types of surgery than lobectomy for non-small cell lung cancer and may have fewer side effects and improve recovery. It is not yet known whether wedge resection or segmentectomy are more effective than lobectomy in treating stage IA non-small cell lung cancer.
The study will compare the Disease Free Survival in the 2 groups.
 
Ontario 
St. Joseph's Hospital
Charlton Campus, Hamilton
 
London Regional Cancer Center
London
 
Princess Margaret Hospital
Toronto
 
Ottawa Regional Cancer Center
Ottawa
 
Quebec 
Hopital Notre-Dame du CHUM
Montreal
 
CHUS-Hopital Fleurimont
Sherbrooke
 
L'Hopital Laval
Laval
 
British Columbia 
Surrey Memorial Hospital
Surrey
 

2. Robotic Lobectomy vs. Thoracoscopic Lobectomy for Early Stage Lung Cancer

      ClinicalTrials.gov Identifier:              NCT02617186      

 
Robotic lobectomy has been shown, on the basis of non-randomized studies, to have superior outcomes to thoracotomy and Thoracoscopic lobectomy. Despite the potential benefits of robotic technology, there are two major barriers against its widespread adoption in thoracic surgery. The first barrier is the lack of high-quality prospective data. To our knowledge, there are no prospective trials comparing Thoracoscopic Lobectomy to Robotic Lobectomy for early stage lung cancer. The second major barrier to the widespread adoption of robotic technology in thoracic surgery is the perceived higher cost of Robotic lobectomy. To address these barriers, the investigators will undertake the first randomized controlled trial comparing Thoracoscopic Lobectomy to Robotic Lobectomy for early stage lung cancer.
 
Prospective randomization will eliminate the biases of retrospective data and will serve to determine whether there exist any advantages to HRQOL or patient outcomes in favour of Robotic Lobectomy over Thoracoscopic Lobectomy. Furthermore, through a prospective cost-utility analysis, this trial will provide the highest quality data to evaluate the true economic impact of robotic technology in thoracic surgery.
 
Ontario 
St Joseph’s Healthcare
Hamilton
 
Toronto General Hospital
Toronto 
 

3. Randomized Study of Preoperative Dexamethasone for Quality of Recovery in VATS Lung Resection Patients (APV)

      ClinicalTrials.gov Identifier:              NCT02275702      

 
The proposed study is a randomized, double-blind, placebo-controlled evaluation if a small dose of IV dexamethasone during induction anesthesia in association to pre and postoperative intercostal nerve block, improves quality of recovery of thoracoscopic lung resection patients.
 
Quebec 
Institut Universitaire de Cardiologie et de Pneumologie de Québec, IUCPQ
 

4. Ultrasonic Energy for Pulmonary Artery Branch Sealing During VATS Lobectomy (VATS PA-ACE)

      ClinicalTrials.gov Identifier:              NCT02719717      

 
This research program consists of a prospective, multi-institutional Phase 2 trial and an economic cost-effectiveness analysis for the use of ACE+7 in VATS lobectomy/segmentectomy compared to traditional techniques.
 
It will be left up to the study credentialed surgeon investigator to decide the suitability of PA branches for sealing. This will be decided intra-operatively based on anatomy, vascular dissection and length as well as patient specific factors.
 
Quebec 
Centre Hospitalier de l'Université de Montréal
Monteal,  H2L 4M1
 

5. Cervical Video Assisted Thoracoscopic Surgery (C-VATS) (CT0030)

      ClinicalTrials.gov Identifier:              NCT01440244      

 
Although thoracic NOTES may not be ready for human trials, a new minimally invasive technique to access the pleural cavity and perform pleural, pulmonary and mediastinal procedures would be possible. Cervical Video Assisted Thoracoscopic Surgery (C-VATS) is a technique that borrows from traditional VATS procedures, from cervical mediastinoscopy, and from flexible endoscopy. All of these procedures are very familiar to the thoracic surgeon.
 
The current feasibility and safety study examines C-VATS as a method of evaluating, biopsying and performing pleurodesis in patients with pleural disease and or effusion.
 
Quebec 
Centre Hospitalier de l'Université de Montréal
Montréal,  H2L 4M1